Adaphostin

Name	Adaphostin
Supplier	Tocris Bioscience
Catalog	2852
Prices	$139.00, $585.00
Sizes	10 mg, 50 mg
Function Type	Inhibitor
Cas Number	241127-58-2
Chemical Name	4-[[(2,5-Dihydroxyphenyl)methyl]amino]benzoicacidtricyclo[3.3.1.13,7]dec-1-ylester
Formula	C24H27NO4
Molecular Weight	393.48
Purity	>98 %
Description	p210 bcr/abl tyrosine kinase inhibitor (IC 50 = 14 μ M). Induces apoptosis in T-lymphoblastic human leukemia cell lines (IC 50 values range from 16.8 to 216.3 nM) in vitro . Displays selectivity for chronic myelogenous leukemia (CML) myeloid progenitors in vitro .
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Product References

Effects of the bcr/abl kinase inhibitors AG957 and NSC 680410 on chronic - Effects of the bcr/abl kinase inhibitors AG957 and NSC 680410 on chronic

Svingen PA, Tefferi A, Kottke TJ, Kaur G, Narayanan VL, Sausville EA, Kaufmann SH. Clin Cancer Res. 2000 Jan;6(1):237-49.

In vitro and in vivo evaluations of the tyrosine kinase inhibitor NSC 680410 - In vitro and in vivo evaluations of the tyrosine kinase inhibitor NSC 680410

Avramis IA, Christodoulopoulos G, Suzuki A, Laug WE, Gonzalez-Gomez I, McNamara G, Sausville EA, Avramis VI. Cancer Chemother Pharmacol. 2002 Dec;50(6):479-89. Epub 2002 Oct 17.

Effects of the Bcr/abl kinase inhibitors STI571 and adaphostin (NSC 680410) on - Effects of the Bcr/abl kinase inhibitors STI571 and adaphostin (NSC 680410) on

Mow BM, Chandra J, Svingen PA, Hallgren CG, Weisberg E, Kottke TJ, Narayanan VL, Litzow MR, Griffin JD, Sausville EA, Tefferi A, Kaufmann SH. Blood. 2002 Jan 15;99(2):664-71.