Adenosine 5'-( α , β -methylene)diphosphate sodium salt

Name Adenosine 5'-( α , β -methylene)diphosphate sodium salt
Supplier Tocris Bioscience
Catalog 3624
Prices $195.00
Sizes 10 mg
Function Type Inhibitor
Cas Number 89016-30-8
Chemical Name α,β-Methyleneadenosine5'-diphosphatemonosodiumsalt
Formula C11H16N5NaO9P2
Molecular Weight 447.21
Purity >98 %
Description Ecto-5'-nucleotidase/CD73 inhibitor. Blocks ecto-5'-nucleotidase-mediated adenosine production by preventing the conversion of AMP to adenosine. Reverses the doxorubicin-resistance in ecto-5'-nucleotidase-positive MDR cells (MCF7/A6 and L1210/A). Also increases rhodamine uptake and inhibits rhodamine efflux from ecto-5'-nucleotidase-positive MDR cells. Vasoconstrictor.
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Product References

Evidence for the involvement of ecto-5'-nucleotidase (CD73) in drug resistance. - Evidence for the involvement of ecto-5'-nucleotidase (CD73) in drug resistance.

Ujhazy P, Berleth ES, Pietkiewicz JM, Kitano H, Skaar JR, Ehrke MJ, Mihich E. Int J Cancer. 1996 Nov 15;68(4):493-500.

IFN-beta regulates CD73 and adenosine expression at the blood-brain barrier. - IFN-beta regulates CD73 and adenosine expression at the blood-brain barrier.

Niemela J, Ifergan I, Yegutkin GG, Jalkanen S, Prat A, Airas L. Eur J Immunol. 2008 Oct;38(10):2718-26.

Purinergic control of vascular tone in the retina. - Purinergic control of vascular tone in the retina.

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