(±)-ADX 71743

Name (±)-ADX 71743
Supplier Tocris Bioscience
Catalog 4416
Prices $175.00, $735.00
Sizes 10 mg, 50 mg
Function Type Modulator
Chemical Name 6-(2,4-Dimethylphenyl)-2-ethyl-6,7-dihydro-4(5H)-benzoxazolone
Formula C17H19NO2
Molecular Weight 269.34
Purity >98 %
Description Negative allosteric modulator at mGlu 7 (IC 50 = 300 nM). Blocks high frequency-induced LTP at SC-CA1 synapses in hippocampal slices in vitro . Increases evoked excitatory postsynaptic currents (eEPSCs) in mice. Brain penetrant.
Supplier Page Shop

Product References

Inhibition of NADPH oxidase activation by 4-(2-aminoethyl)-benzenesulfonyl - Inhibition of NADPH oxidase activation by 4-(2-aminoethyl)-benzenesulfonyl

Diatchuk V, Lotan O, Koshkin V, Wikstroem P, Pick E. J Biol Chem. 1997 May 16;272(20):13292-301.

Serine protease inhibitor attenuates ovalbumin induced inflammation in mouse - Serine protease inhibitor attenuates ovalbumin induced inflammation in mouse

Saw S, Kale SL, Arora N. PLoS One. 2012;7(7):e41107.