AEE 788

• Supplier: Tocris Bioscience
• Catalog: 5175
• Prices: $235.00, $965.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 497839-62-0
• Chemical Name: 6-[4-[(4-Ethyl-1-piperazinyl)methyl]phenyl]-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
• Formula: C27H32N6
• Molecular Weight: 440.58
• Purity: >98 %
• Description: Potent EGFR and VEGFR inhibitor (IC 50 values are 2, 6, 59, 77, 160 and 330 nM for EGFR, ErbB2, VEGFR-1, VEGFR-2, ErbB4 and VEGFR-3 respectively). Also inhibits c-Abl, c-Fms and c-Src (IC 50 values are 52, 60 and 61 nM respectively). Inhibits proliferation of EGFR and ErbB2 overexpressing cancer cell lines in vitro . Inhibits tumor xenograft growth and VEGF-induced angiogenesis in mice. Orally active.

Product References

AEE788: a dual family epidermal growth factor receptor/ErbB2 and vascular - AEE788: a dual family epidermal growth factor receptor/ErbB2 and vascular

Traxler P, Allegrini PR, Brandt R, Brueggen J, Cozens R, Fabbro D, Grosios K, Lane HA, McSheehy P, Mestan J, Meyer T, Tang C, Wartmann M, Wood J, Caravatti G. Cancer Res. 2004 Jul 15;64(14):4931-41.

Dual inhibition of epidermal growth factor receptor and vascular endothelial - Dual inhibition of epidermal growth factor receptor and vascular endothelial

Yokoi K, Thaker PH, Yazici S, Rebhun RR, Nam DH, He J, Kim SJ, Abbruzzese JL, Hamilton SR, Fidler IJ. Cancer Res. 2005 May 1;65(9):3716-25.