AEG 3482

• Supplier: Tocris Bioscience
• Catalog: 5318
• Prices: $129.00, $535.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 63735-71-7
• Chemical Name: 6-Phenylimidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide
• Formula: C10H8N4O2S2
• Molecular Weight: 280.33
• Purity: >99 %
• Description: Inhibitor of c-jun N-terminal kinase (JNK) signaling. Binds Hsp90 and facilitates HSF1 release, induces expression of Hsp70, which in turn blocks JNK activation and JNK-dependent apoptosis. Antiapoptotic; inhibits NGF withdrawal-induced death in SCG neurons (EC 50 = 20 μ M).

Product References

Targeting HSP90 to halt neurodegeneration. - Targeting HSP90 to halt neurodegeneration.

Gallo KA. Chem Biol. 2006 Feb;13(2):115-6.

AEG3482 is an antiapoptotic compound that inhibits Jun kinase activity and cell - AEG3482 is an antiapoptotic compound that inhibits Jun kinase activity and cell

Salehi AH, Morris SJ, Ho WC, Dickson KM, Doucet G, Milutinovic S, Durkin J, Gillard JW, Barker PA. Chem Biol. 2006 Feb;13(2):213-23.