AEG 40730 dihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 2651
• Prices: $265.00, $1,085.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Chemical Name: 222,Trifluoro-N-[[(2S)-1-(N-methyl-L-analyl-L-threonyl)-2-pyrrolidinyl]methyl]-N-(2-phenylethyl)acetamide,diethyletherwith2,4-hexadiyne-1.6-dioldihydrochloride
• Formula: C52H68F6N8O8.2HCl
• Molecular Weight: 1120.06
• Purity: >98 %
• Description: IAP antagonist; binds to the BIR3 domain of cIAP1, cIAP2 and XIAP with nanomolar affinity. Reduces cIAP1, cIAP2 and XIAP protein levels in human breast cancer MDA-MB-231 cells. Induces apoptosis in combination with TNF, and potentiates TRAIL-mediated apoptosis in human colorectal carcinoma HCT 116 cells. Cell permeable.

Product References

cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that - cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that

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Cytoprotective effects of IAPs revealed by a small molecule antagonist. - Cytoprotective effects of IAPs revealed by a small molecule antagonist.

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Smac mimetics and innate immune stimuli synergize to promote tumor death. - Smac mimetics and innate immune stimuli synergize to promote tumor death.

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