AF 12198

• Supplier: Tocris Bioscience
• Catalog: 5330
• Prices: $309.00
• Sizes: 1 mg
• Function Type: Antagonist
• Cas Number: 185413-30-3
• Formula: C96H123N19O22
• Molecular Weight: 1895.14
• Description: Potent and selective antagonist for the human type I interleukin-1 (IL-1) receptor (IC 50 values are 8 nM, > 6.7 mM and > 200 mM for human type I, human type II and murine type I IL-1 receptors respectively). Blocks IL-1-induced expression of ICAM-1 and E-selectin in HUVECs and IL-1 β induction of IL-8 in human dermal fibroblasts. Reduces IL-1 β -induced IL-6 production and exhibits anti-inflammatory activity in vivo .

Product References

AF12198, a novel low molecular weight antagonist, selectively binds the human - AF12198, a novel low molecular weight antagonist, selectively binds the human

Akeson AL, Woods CW, Hsieh LC, Bohnke RA, Ackermann BL, Chan KY, Robinson JL, Yanofsky SD, Jacobs JW, Barrett RW, Bowlin TL. J Biol Chem. 1996 Nov 29;271(48):30517-23.

Low level laser therapy (LLLT) decreases pulmonary microvascular leakage, - Low level laser therapy (LLLT) decreases pulmonary microvascular leakage,

Aimbire F, Ligeiro de Oliveira AP, Albertini R, Correa JC, Ladeira de Campos CB, Lyon JP, Silva JA Jr, Costa MS. Inflammation. 2008 Jun;31(3):189-97.