AF-DX 116

• Supplier: Tocris Bioscience
• Catalog: 1793
• Prices: $155.00, $645.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 102394-31-0
• Chemical Name: 11-[[2-[(Diethylamino)methyl]-1-piperidinyl]acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
• Formula: C24H31N5O2
• Molecular Weight: 421.54
• Purity: >98 %
• Description: Selective M 2 muscarinic receptor antagonist. K i values are 64, 417, 786, 211 and 5130 nM for human recombinant M 2 , M 1 , M 3 , M 4 and M 5 muscarinic receptors, respectively.

Product References

Binding profile of a novel cardioselective muscarine receptor antagonist, AF-DX - Binding profile of a novel cardioselective muscarine receptor antagonist, AF-DX

Hammer R, Giraldo E, Schiavi GB, Monferini E, Ladinsky H. Life Sci. 1986 May 5;38(18):1653-62.

Identification of the primary muscarinic autoreceptor subtype in rat striatum as - Identification of the primary muscarinic autoreceptor subtype in rat striatum as

Billard W, Binch H 3rd, Crosby G, McQuade RD. J Pharmacol Exp Ther. 1995 Apr;273(1):273-9.

Muscarinic receptor subtypes and smooth muscle function. - Muscarinic receptor subtypes and smooth muscle function.

Eglen RM, Hegde SS, Watson N. Pharmacol Rev. 1996 Dec;48(4):531-65.

Muscarinic receptor subtypes in human bladder detrusor and mucosa, studied by - Muscarinic receptor subtypes in human bladder detrusor and mucosa, studied by

Mansfield KJ, Liu L, Mitchelson FJ, Moore KH, Millard RJ, Burcher E. Br J Pharmacol. 2005 Apr;144(8):1089-99.