AF-DX 384

• Supplier: Tocris Bioscience
• Catalog: 1105
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 118290-26-9
• Chemical Name: N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide
• Formula: C27H38N6O2
• Molecular Weight: 478.64
• Purity: >98 %
• Description: Potent M 2 /M 4 selective antagonist (pK i values are 8.22, 8.00, 7.51, 7.18 and 6.27 at human M 2 , M 4 , M 1 , M 3 and M 5 receptors respectively).

Product References

Binding of [3H]AF-DX 384 to cloned and native muscarinic receptors. - Binding of [3H]AF-DX 384 to cloned and native muscarinic receptors.

Miller JH, Gibson VA, McKinney M. J Pharmacol Exp Ther. 1991 Nov;259(2):601-7.

AF-DX 384 binding in rabbit cingulate cortex: two site kinetics and section - AF-DX 384 binding in rabbit cingulate cortex: two site kinetics and section

Dopke KL, Vrana KE, Vogt LJ, Vogt BA. J Pharmacol Exp Ther. 1995 Jul;274(1):562-9.

Regional changes in the cholinergic system in mice lacking monoamine oxidase A. - Regional changes in the cholinergic system in mice lacking monoamine oxidase A.

Grailhe R, Cardona A, Even N, Seif I, Changeux JP, Cloez-Tayarani I. Brain Res Bull. 2009 Mar 30;78(6):283-9.