| Name | AG 045572 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 1345 |
| Prices | $105.00, $225.00 |
| Sizes | 1 mg, 10 mg |
| Function Type | Antagonist |
| Cas Number | 263847-55-8 |
| Chemical Name | 5-[5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl-methyl]-N-(2,4,6-trimethoxyphenyl)-2-furancarboxamide |
| Formula | C30H37NO5 |
| Molecular Weight | 491.62 |
| Purity | >97 % |
| Description | Selective gonadotropin-releasing hormone (GnRH) receptor antagonist (K i values are 2.2, 3.8 and 6.0 nM for mouse, rat and human receptors respectively). Suppresses testosterone and luteinising hormone (LH) levels in vivo . |
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Iatsimirskaia EA, Gregory ML, Anderes KL, Castillo R, Milgram KE, Luthin DR, Pathak VP, Christie LC, Vazir H, Anderson MB, May JM. Pharm Res. 2002 Feb;19(2):202-8.
Anderes KL, Luthin DR, Castillo R, Kraynov EA, Castro M, Nared-Hood K, Gregory ML, Pathak VP, Christie LC, Paderes G, Vazir H, Ye Q, Anderson MB, May JM. J Pharmacol Exp Ther. 2003 May;305(2):688-95. Epub 2003 Jan 24.