AG 18

• Supplier: Tocris Bioscience
• Catalog: 1276
• Prices: $125.00, $525.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 118409-57-7
• Chemical Name: [(3,4-Dihydroxyphenyl)methylene]-propenedinitrile
• Formula: C10H6N2O2
• Molecular Weight: 186.17
• Description: Inhibitor of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR) kinase (IC 50 values are 35 and 25 μ M respectively). Inhibits EGF-stimulated cell proliferation. Also acts as a mitochondrial uncoupler that alters phosphorylation-dependent cell signaling.

Product References

Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors. - Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors.

Yaish P, Gazit A, Gilon C, Levitzki A. Science. 1988 Nov 11;242(4880):933-5.

Tyrphostins inhibit epidermal growth factor (EGF)-receptor tyrosine kinase - Tyrphostins inhibit epidermal growth factor (EGF)-receptor tyrosine kinase

Lyall RM, Zilberstein A, Gazit A, Gilon C, Levitzki A, Schlessinger J. J Biol Chem. 1989 Aug 25;264(24):14503-9.

Tyrphostins I: synthesis and biological activity of protein tyrosine kinase - Tyrphostins I: synthesis and biological activity of protein tyrosine kinase

Gazit A, Yaish P, Gilon C, Levitzki A. J Med Chem. 1989 Oct;32(10):2344-52.

Tyrosine kinase inhibition: an approach to drug development. - Tyrosine kinase inhibition: an approach to drug development.

Levitzki A, Gazit A. Science. 1995 Mar 24;267(5205):1782-8.

Evidence that tyrphostins AG10 and AG18 are mitochondrial uncouplers that alter - Evidence that tyrphostins AG10 and AG18 are mitochondrial uncouplers that alter

Soltoff SP. J Biol Chem. 2004 Mar 19;279(12):10910-8. Epub 2003 Dec 19.