Alfuzosin hydrochloride

Name Alfuzosin hydrochloride
Supplier Tocris Bioscience
Catalog 4159
Prices $95.00, $399.00
Sizes 10 mg, 50 mg
Function Type Antagonist
Cas Number 81403-68-1
Chemical Name N-[3-[(4-Amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl]tetrahydro-2-furancarboxamidehydrochloride
Formula C19H27N5O4.HCl
Molecular Weight 425.91
Purity >99 %
Description Functionally uro-selective α 1 adrenoceptor antagonist that does not discriminate between α 1 subtypes. Inhibits increases in intraurethral pressure caused by phenylephrine-induced contraction by 81% with minor cardiovascular effects. Also relaxes corpus cavernosum tissue (pIC 50 = 7.64) in vitro .
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Product References

Alfuzosin hydrochloride for the treatment of benign prostatic hyperplasia. - Alfuzosin hydrochloride for the treatment of benign prostatic hyperplasia.

Lee M. Am J Health Syst Pharm. 2003 Jul 15;60(14):1426-39.

Comparison of the relaxant effects of alfuzosin, phentolamine and sildenafil on - Comparison of the relaxant effects of alfuzosin, phentolamine and sildenafil on

Palea S, Barras M. BJU Int. 2003 Jun;91(9):873-7.

Effects of different alpha-1 adrenoceptor blockers on proximal urethral function - Effects of different alpha-1 adrenoceptor blockers on proximal urethral function

Yamaguchi T, Nagano M, Osada Y. J Smooth Muscle Res. 2005 Oct;41(5):247-56.