Aliskiren hemifumarate

• Supplier: Tocris Bioscience
• Catalog: 3305
• Prices: $185.00, $755.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 173334-58-2
• Chemical Name: (αS,γS,δS,ζS)-δ-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)benzeneoctanamidehemifumarate
• Formula: C30H53N3O6.1/2C4H4O4
• Molecular Weight: 609.83
• Purity: >99 %
• Description: Potent renin inhibitor (IC 50 = 0.6 and 80 nM for human and rat respectively). Exhibits selectivity for renin over a range of other aspartic proteinases (>5000 nM). Lowers blood pressure in a hypertensive rodent model. Orally active.

Product References

Aliskiren: the first renin inhibitor for clinical treatment. - Aliskiren: the first renin inhibitor for clinical treatment.

Jensen C, Herold P, Brunner HR. Nat Rev Drug Discov. 2008 May;7(5):399-410.

Drug discovery for heart failure: a new era or the end of the pipeline? - Drug discovery for heart failure: a new era or the end of the pipeline?

Kaye DM, Krum H. Nat Rev Drug Discov. 2007 Feb;6(2):127-39.