Alrestatin

Name Alrestatin
Supplier Tocris Bioscience
Catalog 1620
Prices $129.00, $535.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 51411-04-2
Chemical Name 1,3-Dioxo-1H-benz[d,e]isoquinoline-2(3H)-aceticacid
Formula C14H9NO4
Molecular Weight 255.23
Description Specific inhibitor of aldose reductase (IC 50 = 148 μ M). Attenuates glucose-induced angiotensin II production in rat vascular smooth muscle in vitro .
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Product References

Mechanism of aldose reductase inhibition: binding of NADP+/NADPH and - Mechanism of aldose reductase inhibition: binding of NADP+/NADPH and

Ehrig T, Bohren KM, Prendergast FG, Gabbay KH. Biochemistry. 1994 Jun 14;33(23):7157-65.

The C-terminal loop of aldehyde reductase determines the substrate and inhibitor - The C-terminal loop of aldehyde reductase determines the substrate and inhibitor

Barski OA, Gabbay KH, Bohren KM. Biochemistry. 1996 Nov 12;35(45):14276-80.

Mechanism of high glucose induced angiotensin II production in rat vascular - Mechanism of high glucose induced angiotensin II production in rat vascular

Lavrentyev EN, Estes AM, Malik KU. Circ Res. 2007 Aug 31;101(5):455-64. Epub 2007 Jul 12.