Altanserin hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 0485
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 1135280-78-2
• Chemical Name: 3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-4(1H)-quinazolinonehydrochloride
• Formula: C22H22FN3O2S.HCl
• Molecular Weight: 447.95
• Purity: >98 %
• Description: Potent and selective 5-HT 2A receptor antagonist (K i values are 0.13, 4.55, 40, 62 and 1570 nM at 5-HT 2A , α 1 , 5-HT 2C , D 2 and 5-HT 1A respectively). Centrally active following systemic administration in vivo .

Product References

Involvement of 5-HT2 receptors in the LSD- and L-5-HTP-induced suppression of - Involvement of 5-HT2 receptors in the LSD- and L-5-HTP-induced suppression of

Sietnieks A. J Neural Transm. 1985;61(1-2):65-80.

Stimulation of corticosterone and beta-endorphin secretion in the rat by - Stimulation of corticosterone and beta-endorphin secretion in the rat by

Koenig JI, Gudelsky GA, Meltzer HY. Eur J Pharmacol. 1987 May 7;137(1):1-8.

Evidence that 5-HT2c receptor antagonists are anxiolytic in the rat - Evidence that 5-HT2c receptor antagonists are anxiolytic in the rat

Kennett GA, Pittaway K, Blackburn TP. Psychopharmacology (Berl). 1994 Feb;114(1):90-6.

Synthesis and in vitro affinities of various MDL 100907 derivatives as potential - Synthesis and in vitro affinities of various MDL 100907 derivatives as potential

Herth MM, Kramer V, Piel M, Palner M, Riss PJ, Knudsen GM, Rosch F. Bioorg Med Chem. 2009 Apr 15;17(8):2989-3002.