ALX 5407 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 1809
• Prices: $189.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 200006-08-2
• Chemical Name: N-[(3R)-3-([1,1'-Biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl]-N-methylglycinehydrochloride
• Formula: C24H24FNO3.HCl
• Molecular Weight: 429.92
• Purity: >98 %
• Description: Selective non-transportable inhibitor of the glycine transporter GlyT1 (IC 50 values are 3 nM and > 100 μ M for human GlyT1c and GlyT2 respectively). Does not recognize other glycine sites, including the glycine site on the NMDA receptor (IC 50 > 100 μ M).

Product References

ALX 5407: a potent, selective inhibitor of the hGlyT1 glycine transporter. - ALX 5407: a potent, selective inhibitor of the hGlyT1 glycine transporter.

Atkinson BN, Bell SC, De Vivo M, Kowalski LR, Lechner SM, Ognyanov VI, Tham CS, Tsai C, Jia J, Ashton D, Klitenick MA. Mol Pharmacol. 2001 Dec;60(6):1414-20.

Modulators of the glycine site on NMDA receptors, D-serine and ALX 5407, display - Modulators of the glycine site on NMDA receptors, D-serine and ALX 5407, display

Lipina T, Labrie V, Weiner I, Roder J. Psychopharmacology (Berl). 2005 Apr;179(1):54-67. Epub 2005 Mar 10.