AM 1172

• Supplier: Tocris Bioscience
• Catalog: 2564
• Prices: $199.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 251908-92-6
• Chemical Name: N-(5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraen-1-yl-4-hydroxybenzamide
• Formula: C27H39NO2
• Molecular Weight: 409.6
• Purity: >98 %
• Description: Metabolically stable anandamide uptake inhibitor (IC 50 = 2.1 - 2.5 μ M) and fatty acid amide hydrolase (FAAH) inhibitor (K i = 3.18 μ M). Inhibits N -arachidonylethanolamine (AEA) accumulation (IC 50 = 24 μ M) and hydrolysis (K i = 3 μ M), and inhibits N -palmitoylethanolamine (PEA) hydrolysis (IC 50 = 36 μ M) in cerebellar granule neurons. Also acts as a non-selective cannabinoid receptor partial agonist (EC 50 values are 189 and 271 nM at CB 2 and CB 1 receptors respectively).

Product References

Anandamide uptake is consistent with rate-limited diffusion and is regulated by - Anandamide uptake is consistent with rate-limited diffusion and is regulated by

Kaczocha M, Hermann A, Glaser ST, Bojesen IN, Deutsch DG. J Biol Chem. 2006 Apr 7;281(14):9066-75. Epub 2006 Feb 6.

Studies of anandamide accumulation inhibitors in cerebellar granule neurons: - Studies of anandamide accumulation inhibitors in cerebellar granule neurons:

Hillard CJ, Shi L, Tuniki VR, Falck JR, Campbell WB. J Mol Neurosci. 2007 Sep;33(1):18-24.