AM 281

• Supplier: Tocris Bioscience
• Catalog: 1117
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 202463-68-1
• Chemical Name: 1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-1H-pyrazole-3-carboxamide
• Formula: C21H19Cl2IN4O2
• Molecular Weight: 557.22
• Purity: >99 %
• Description: Potent, selective CB 1 cannabinoid receptor antagonist/inverse agonist (K i values are 12 and 4200 nM for CB 1 and CB 2 receptors respectively). Increases locomotor activity following systemic administration in vivo . Analog of SR141716A (K i = 14 nM).

Product References

Effect of the cannabinoid receptor SPECT agent, AM 281, on hippocampal - Effect of the cannabinoid receptor SPECT agent, AM 281, on hippocampal

Gifford AN, Tang Y, Gatley SJ, Volkow ND, Lan R, Makriyannis A. Neurosci Lett. 1997 Nov 28;238(1-2):84-6.

Imaging the brain marijuana receptor: development of a radioligand that binds to - Imaging the brain marijuana receptor: development of a radioligand that binds to

Gatley SJ, Lan R, Volkow ND, Pappas N, King P, Wong CT, Gifford AN, Pyatt B, Dewey SL, Makriyannis A. J Neurochem. 1998 Jan;70(1):417-23.

Design and synthesis of the CB1 selective cannabinoid antagonist AM281: a - Design and synthesis of the CB1 selective cannabinoid antagonist AM281: a

Lan R, Gatley J, Lu Q, Fan P, Fernando SR, Volkow ND, Pertwee R, Makriyannis A. AAPS PharmSci. 1999;1(2):E4.

Locomotor activity and occupancy of brain cannabinoid CB1 receptors by the - Locomotor activity and occupancy of brain cannabinoid CB1 receptors by the

Cosenza M, Gifford AN, Gatley SJ, Pyatt B, Liu Q, Makriyannis A, Volkow ND. Synapse. 2000 Dec 15;38(4):477-82.