AM 404

• Supplier: Tocris Bioscience
• Catalog: 1115
• Prices: $89.00, $375.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 198022-70-7
• Chemical Name: N-(4-Hydroxyphenyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
• Formula: C26H37NO2
• Molecular Weight: 395.58
• Purity: >98 %
• Description: Competitive and selective inhibitor of carrier-mediated anandamide transport (IC 50 = 1 μ M). Does not activate CB 1 receptors or inhibit anandamide hydrolysis but has been shown to activate native and cloned vanilloid receptors (pEC 50 = 7.4). Active in vivo . Also available in water soluble emulsion (Cat. No. 1685).

Product References

Functional role of high-affinity anandamide transport, as revealed by selective - Functional role of high-affinity anandamide transport, as revealed by selective

Beltramo M, Stella N, Calignano A, Lin SY, Makriyannis A, Piomelli D. Science. 1997 Aug 22;277(5329):1094-7.

Potentiation of anandamide hypotension by the transport inhibitor, AM404. - Potentiation of anandamide hypotension by the transport inhibitor, AM404.

Calignano A, La Rana G, Beltramo M, Makriyannis A, Piomelli D. Eur J Pharmacol. 1997 Oct 15;337(1):R1-2.

Structural determinants for recognition and translocation by the anandamide - Structural determinants for recognition and translocation by the anandamide

Piomelli D, Beltramo M, Glasnapp S, Lin SY, Goutopoulos A, Xie XQ, Makriyannis A. Proc Natl Acad Sci U S A. 1999 May 11;96(10):5802-7.

The anandamide transport inhibitor AM404 activates vanilloid receptors. - The anandamide transport inhibitor AM404 activates vanilloid receptors.

Zygmunt PM, Chuang H, Movahed P, Julius D, Hogestatt ED. Eur J Pharmacol. 2000 May 12;396(1):39-42.