AM 4668

• Supplier: Tocris Bioscience
• Catalog: 1116
• Prices: $189.00, $795.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 1011531-27-3
• Chemical Name: (βS)-β-[4-[[4-Methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methoxy]phenyl)-3-isoxazolepropanoicacid
• Formula: C24H19F3O4S
• Molecular Weight: 488.48
• Purity: >98 %
• Description: Potent FFA1 (GPR40) agonist (EC 50 = 3.6 nM in an IP 3 assay in GPR40 transfected A9 cells). Inhibits insulin secretion from isolated pancreatic islets. Reduces blood glucose levels following oral glucose challenge in mice. Orally bioavailable.

Product References

Functional role of high-affinity anandamide transport, as revealed by selective - Functional role of high-affinity anandamide transport, as revealed by selective

Beltramo M, Stella N, Calignano A, Lin SY, Makriyannis A, Piomelli D. Science. 1997 Aug 22;277(5329):1094-7.

Potentiation of anandamide hypotension by the transport inhibitor, AM404. - Potentiation of anandamide hypotension by the transport inhibitor, AM404.

Calignano A, La Rana G, Beltramo M, Makriyannis A, Piomelli D. Eur J Pharmacol. 1997 Oct 15;337(1):R1-2.

Structural determinants for recognition and translocation by the anandamide - Structural determinants for recognition and translocation by the anandamide

Piomelli D, Beltramo M, Glasnapp S, Lin SY, Goutopoulos A, Xie XQ, Makriyannis A. Proc Natl Acad Sci U S A. 1999 May 11;96(10):5802-7.

The anandamide transport inhibitor AM404 activates vanilloid receptors. - The anandamide transport inhibitor AM404 activates vanilloid receptors.

Zygmunt PM, Chuang H, Movahed P, Julius D, Hogestatt ED. Eur J Pharmacol. 2000 May 12;396(1):39-42.