AM 630

• Supplier: Tocris Bioscience
• Catalog: 0760
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 164178-33-0
• Chemical Name: 6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)methanone
• Formula: C23H25IN2O3
• Molecular Weight: 504.37
• Purity: >98 %
• Description: CB 2 antagonist/inverse agonist (K i = 31.2 nM) that displays 165-fold selectivity over CB 1 receptors. Behaves as a weak partial/inverse agonist at CB 1 receptors.

Product References

AM630 is a competitive cannabinoid receptor antagonist in the guinea pig brain. - AM630 is a competitive cannabinoid receptor antagonist in the guinea pig brain.

Hosohata K, Quock RM, Hosohata Y, Burkey TH, Makriyannis A, Consroe P, Roeske WR, Yamamura HI. Life Sci. 1997;61(9):PL115-8.

AM630 antagonism of cannabinoid-stimulated [35S]GTP gamma S binding in the mouse - AM630 antagonism of cannabinoid-stimulated [35S]GTP gamma S binding in the mouse

Hosohata Y, Quock RM, Hosohata K, Makriyannis A, Consroe P, Roeske WR, Yamamura HI. Eur J Pharmacol. 1997 Feb 19;321(1):R1-3.

AM630 is an inverse agonist at the human cannabinoid CB1 receptor. - AM630 is an inverse agonist at the human cannabinoid CB1 receptor.

Landsman RS, Makriyannis A, Deng H, Consroe P, Roeske WR, Yamamura HI. Life Sci. 1998;62(9):PL109-13.

Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of - Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of

Ross RA, Brockie HC, Stevenson LA, Murphy VL, Templeton F, Makriyannis A, Pertwee RG. Br J Pharmacol. 1999 Feb;126(3):665-72.