AM 6545

• Supplier: Tocris Bioscience
• Catalog: 1120
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 1245626-05-4
• Chemical Name: 5-[4-(4-Cyano-1-butyn-1-yl)phenyl]-1-(2,4-dichlorophenyl)-N-(1,1-dioxido-4-thiomorpholinyl)-4-methyl-1H-pyrazole-3-carboxamide
• Formula: C26H23Cl2N5O3S
• Molecular Weight: 556.46
• Purity: >98 %
• Description: High affinity and selective CB 1 antagonist (K i = 3.3 nM). Exhibits >100-fold selectivity for CB 1 over CB 2 receptors. Improves glucose homeostasis, reverses hepatic steatosis and reduces body weight in diet-induced obese mice. Orally available and non-brain penetrant.

Product References

Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in - Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in

Tam J, Vemuri VK, Liu J, Batkai S, Mukhopadhyay B, Godlewski G, Osei-Hyiaman D, Ohnuma S, Ambudkar SV, Pickel J, Makriyannis A, Kunos G. J Clin Invest. 2010 Aug;120(8):2953-66.

A peripheral endocannabinoid mechanism contributes to glucocorticoid-mediated - A peripheral endocannabinoid mechanism contributes to glucocorticoid-mediated

Bowles NP, Karatsoreos IN, Li X, Vemuri VK, Wood JA, Li Z, Tamashiro KL, Schwartz GJ, Makriyannis AM, Kunos G, Hillard CJ, McEwen BS, Hill MN. Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):285-90.