AM 80

Name AM 80
Supplier Tocris Bioscience
Catalog 5443
Prices $175.00, $709.00
Sizes 10 mg, 50 mg
Function Type Agonist
Cas Number 94497-51-5
Chemical Name 4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)amino]carbonyl]benzoicacid
Formula C22H25NO3
Molecular Weight 351.44
Purity >99 %
Description Retinoic acid receptor α (RAR α ) agonist that induces differentiation (ED 50 = 0.79 nM) and apoptosis of HL-60 cells in vitro . Exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 μ M respectively) and displays anticancer activity against acute promyelocytic leukemia in vivo .
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Product References

Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with - Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with

Kagechika H, Kawachi E, Hashimoto Y, Himi T, Shudo K. J Med Chem. 1988 Nov;31(11):2182-92.

RARalpha is a regulatory factor for Am-80-induced cell growth inhibition of - RARalpha is a regulatory factor for Am-80-induced cell growth inhibition of

Jimi S, Mashima K, Matsumoto T, Hara S, Suzumiya J, Tamura K. Int J Oncol. 2007 Aug;31(2):397-404.

The effect of Am-80, a synthetic retinoid, on spinal cord injury-induced motor - The effect of Am-80, a synthetic retinoid, on spinal cord injury-induced motor

Takenaga M, Ohta Y, Tokura Y, Hamaguchi A, Shudo K, Okano H, Igarashi R. Biol Pharm Bull. 2009 Feb;32(2):225-31.