Ambenonium dichloride

• Supplier: Tocris Bioscience
• Catalog: 4025
• Prices: $129.00, $535.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 115-79-7
• Chemical Name: N,N'-[(1,2-Dioxo-1,2-ethanediyl)bis(imino-2,1-ethanediyl)]bis(2-chloro-N,N-diethylbenzenemethaminium)dichloride
• Formula: C28H42Cl4N4O2
• Molecular Weight: 608.48
• Purity: >99 %
• Description: Extremely potent, selective and rapidly reversible inhibitor of acetylcholinesterase (AChE) (IC 50 values are 0.000698 and 8.20 μ M at AChE and BChE respectively).

Product References

An investigation of the structure-activity correlations within a series of - An investigation of the structure-activity correlations within a series of

LANDS AM, HOPPE JO, ARNOLD A, KIRCHNER FK. J Pharmacol Exp Ther. 1958 Jun;123(2):121-7.

Affinity of benzoquinonium and ambenonium derivatives for the acetylcholine - Affinity of benzoquinonium and ambenonium derivatives for the acetylcholine

Webb GD. Biochim Biophys Acta. 1965 May 25;102(1):172-84.

Ambenonium is a rapidly reversible noncovalent inhibitor of acetylcholinesterase, - Ambenonium is a rapidly reversible noncovalent inhibitor of acetylcholinesterase,

Hodge AS, Humphrey DR, Rosenberry TL. Mol Pharmacol. 1992 May;41(5):937-42.

Design, synthesis and biological evaluation of ambenonium derivatives as AChE - Design, synthesis and biological evaluation of ambenonium derivatives as AChE

Bolognesi ML, Cavalli A, Andrisano V, Bartolini M, Banzi R, Antonello A, Rosini M, Melchiorre C. Farmaco. 2003 Sep;58(9):917-28.