AMD 3100 octahydrochloride

• Supplier: Tocris Bioscience
• Catalog: 2404
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 155148-31-5
• Chemical Name: 1,1'-[1,4-Phenylenebis-(methylene)]-bis-(1,4,8,11-tetraazacyclotetradecane)octahydrochloride
• Formula: C28H54N8.8HCl
• Molecular Weight: 794.48
• Description: Highly selective CXCR4 chemokine receptor antagonist (IC 50 values are 0.02 - 0.13 and > 25 μ M for CXCR4 and all other chemokine receptors respectively). Switches inflammatory responses from Th2 to Th1 type and reduces airway hyperresponsiveness in a mouse model of asthma. Potently inhibits HIV-1 and HIV-2 replication in vitro (EC 50 = 4 - 35 nM) and mobilizes hematopoietic stem cells in vivo .

Product References

Synthesis and structure-activity relationships of phenylenebis(methylene)-linked - Synthesis and structure-activity relationships of phenylenebis(methylene)-linked

Bridger GJ, Skerlj RT, Thornton D, Padmanabhan S, Martellucci SA, Henson GW, Abrams MJ, Yamamoto N, De Vreese K, Pauwels R, et al.. J Med Chem. 1995 Jan 20;38(2):366-78.

The therapeutic potential in targeting CCR5 and CXCR4 receptors in infectious and - The therapeutic potential in targeting CCR5 and CXCR4 receptors in infectious and

Hogaboam CM, Carpenter KJ, Schuh JM, Proudfoot AA, Bridger G, Buckland KF. Pharmacol Ther. 2005 Sep;107(3):314-28.

Effective mobilization of hematopoietic progenitor cells in G-CSF mobilization - Effective mobilization of hematopoietic progenitor cells in G-CSF mobilization

Paganessi LA, Walker AL, Tan LL, Holmes I, Rich E, Fung HC, Christopherson KW 2nd. Exp Hematol. 2011 Mar;39(3):384-90.