AMD 3465 hexahydrobromide

• Supplier: Tocris Bioscience
• Catalog: 3299
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 185991-07-5
• Chemical Name: N-[[4-(1,4,8,11-Tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-2-pyridinemethanaminehexahydrobromide
• Formula: C24H38N6.6HBr
• Molecular Weight: 896.07
• Purity: >97 %
• Description: Potent, selective CXCR4 antagonist; exhibits 8-fold higher affinity than AMD 3100 (Cat.No. 3299). Inhibits SDF-1 α -ligand binding (K i = 41.7 nM). Potently inhibits HIV cell entry in vitro ; causes leukocytosis and mobilizes haematopoietic stem cells in vivo .

Product References

Molecular mechanism of action of monocyclam versus bicyclam non-peptide - Molecular mechanism of action of monocyclam versus bicyclam non-peptide

Rosenkilde MM, Gerlach LO, Hatse S, Skerlj RT, Schols D, Bridger GJ, Schwartz TW. J Biol Chem. 2007 Sep 14;282(37):27354-65. Epub 2007 Jun 28.

Pharmacology of AMD3465: a small molecule antagonist of the chemokine receptor - Pharmacology of AMD3465: a small molecule antagonist of the chemokine receptor

Bodart V, Anastassov V, Darkes MC, Idzan SR, Labrecque J, Lau G, Mosi RM, Neff KS, Nelson KL, Ruzek MC, Patel K, Santucci Z, Scarborough R, Wong RS, Bridger GJ, Macfarland RT, Fricker SP. Biochem Pharmacol. 2009 Oct 15;78(8):993-1000.