AMG 21629

• Supplier: Tocris Bioscience
• Catalog: 4179
• Prices: $345.00
• Sizes: 1 mg
• Function Type: Antagonist
• Cas Number: 939040-79-6
• Chemical Name: 3-Amino-5-[[2-[(2-methoxyethyl)amino]-6-[4-(trifluoromethyl)phenyl]-4-pyrimidinyl]oxy]-2(1H)-quinoxalinone
• Formula: C22H19F3N6O3
• Molecular Weight: 472.42
• Purity: >97 %
• Description: Potent and selective TRPV1 antagonist. Blocks Ca 2+ uptake by CHO cells expressing TRPV1 receptors (IC 50 values are 0.6 and 0.8 nM for capsaicin (Cat. No. 0462) and acid-induced Ca 2+ uptake, respectively). Exhibits >4000-fold selectivity for TRPV1 over other TRP channels. Blocks capsaicin-induced flinch response and causes hyperthermia in rats. Orally available and non-CNS penetrant.

Product References

Antagonism of CXCR3 inhibits lung metastasis in a murine model of metastatic - Antagonism of CXCR3 inhibits lung metastasis in a murine model of metastatic

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Discovery and optimization of a series of quinazolinone-derived antagonists of - Discovery and optimization of a series of quinazolinone-derived antagonists of

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Organ-specific inhibition of metastatic colon carcinoma by CXCR3 antagonism. - Organ-specific inhibition of metastatic colon carcinoma by CXCR3 antagonism.

Cambien B, Karimdjee BF, Richard-Fiardo P, Bziouech H, Barthel R, Millet MA, Martini V, Birnbaum D, Scoazec JY, Abello J, Al Saati T, Johnson MG, Sullivan TJ, Medina JC, Collins TL, Schmid-Alliana A, Schmid-Antomarchi H. Br J Cancer. 2009 Jun 2;100(11):1755-64.