AMG 517

• Supplier: Tocris Bioscience
• Catalog: 4487
• Prices: $169.00, $715.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 659730-32-2
• Chemical Name: N-[4-[[6-[4-(Trifluoromethyl)phenyl]-4-pyrimidinyl]oxy]-2-benzothiazolyl]acetamide
• Formula: C20H13F3N4O2S
• Molecular Weight: 430.41
• Purity: >98 %
• Description: Potent TRPV1 antagonist (IC 50 = 0.9 nM). Inhibits capsaican-induced flinching and reverses analgesia in an inflammatory pain model in rats. Orally bioavailable.

Product References

p38 MAP kinase inhibitors: many are made, but few are chosen. - p38 MAP kinase inhibitors: many are made, but few are chosen.

Dominguez C, Powers DA, Tamayo N. Curr Opin Drug Discov Devel. 2005 Jul;8(4):421-30.

MAP kinase p38 inhibitors: clinical results and an intimate look at their - MAP kinase p38 inhibitors: clinical results and an intimate look at their

Lee MR, Dominguez C. Curr Med Chem. 2005;12(25):2979-94.