AMG PERK 44

Name AMG PERK 44
Supplier Tocris Bioscience
Catalog 2316
Prices $229.00, $945.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Chemical Name 4-[2-Amino-4-methyl-3-(2-methyl-6-quinolinyl)benzoyl]-1,2-dihydro-1-methyl-2,5-diphenyl-3H-pyrazol-3-onehydrochloride
Formula C34H28N4O2.HCl
Molecular Weight 561.07
Purity >98 %
Description Potent and selective PERK inhibitor (IC 50 = 6 nM). Exhibits >160-fold selectivity for PERK over B-Raf and GCN2, as well as a panel of 387 other kinases. Orally bioavailable.
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Product References

Antagonism of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane stimulus with a - Antagonism of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane stimulus with a

Ismaiel AM, De Los Angeles J, Teitler M, Ingher S, Glennon RA. J Med Chem. 1993 Aug 20;36(17):2519-25.

Behavioral effects of AMI-193, a 5-HT(2A)- and dopamine D(2)-receptor antagonist, - Behavioral effects of AMI-193, a 5-HT(2A)- and dopamine D(2)-receptor antagonist,

Czoty PW, Howell LL. Pharmacol Biochem Behav. 2000 Oct;67(2):257-64.