| Name | Aminopurvalanol A |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 0721 |
| Prices | $205.00, $845.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 220792-57-4 |
| Chemical Name | (2R)-2-[[6-[(3-Amino-5-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol |
| Formula | C19H26ClN7O |
| Molecular Weight | 403.91 |
| Purity | >98 % |
| Description | Cell-permeable cyclin-dependent kinase inhibitor. IC 50 values are 0.033, 0.033, 0.028 and 0.020 μ M for cdk1/cyclin B, cdk2/cyclin A, cdk2/cyclin E, and cdk5/p35 respectively. Inhibits ERK1 (IC 50 = 12.0 μ M) and ERK2 (IC 50 = 3.1 μ M) and is 3000-fold selective over a range of other protein kinases (IC 50 > 100 μ M). Arrests cell cycle at G 2 /M boundary (IC 50 = 1.25 μ M), and induces apoptosis at concentrations > 10 μ M. |
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Chang YT, Gray NS, Rosania GR, Sutherlin DP, Kwon S, Norman TC, Sarohia R, Leost M, Meijer L, Schultz PG. Chem Biol. 1999 Jun;6(6):361-75.
Knockaert M, Gray N, Damiens E, Chang YT, Grellier P, Grant K, Fergusson D, Mottram J, Soete M, Dubremetz JF, Le Roch K, Doerig C, Schultz P, Meijer L. Chem Biol. 2000 Jun;7(6):411-22.