4-Aminopyridine

Name 4-Aminopyridine
Supplier Tocris Bioscience
Catalog 2072
Prices $75.00
Sizes 100 mg
Function Type Blocker
Cas Number 504-24-5
Formula C5H6N2
Molecular Weight 94.12
Purity >99 %
Description Non-selective voltage-dependent K + -channel blocker (IC 50 values are 170 and 230 μ M at K V 1.1 and K V 1.2 respectively). Caged 4-AP (Cat. No. 3557) is also available.
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Product References

Closed- and open-state binding of 4-aminopyridine to the cloned human potassium - Closed- and open-state binding of 4-aminopyridine to the cloned human potassium

Bouchard R, Fedida D. J Pharmacol Exp Ther. 1995 Nov;275(2):864-76.

Reverse use dependence of Kv4.2 blockade by 4-aminopyridine. - Reverse use dependence of Kv4.2 blockade by 4-aminopyridine.

Tseng GN, Jiang M, Yao JA. J Pharmacol Exp Ther. 1996 Nov;279(2):865-76.

Different state dependencies of 4-aminopyridine binding to rKv1.4 and rKv4.2: - Different state dependencies of 4-aminopyridine binding to rKv1.4 and rKv4.2:

Tseng GN. J Pharmacol Exp Ther. 1999 Aug;290(2):569-77.

In Vitro electrophysiological activity of nerispirdine, a novel 4-aminopyridine - In Vitro electrophysiological activity of nerispirdine, a novel 4-aminopyridine

Smith C, Kongsamut S, Wang H, Ji J, Kang J, Rampe D. Clin Exp Pharmacol Physiol. 2009 Nov;36(11):1104-9. doi: