| Name | Amisulpride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4095 |
| Prices | $115.00 |
| Sizes | 50 mg |
| Function Type | Antagonist |
| Cas Number | 71675-85-9 |
| Chemical Name | 4-Amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-benzamide |
| Formula | C17H27N3O4S |
| Molecular Weight | 369.48 |
| Purity | >98 % |
| Description | Potent, selective dopamine D 2 and D 3 receptor antagonist. K i values are 2.8 and 3.2 nM respectively for human D 2 and D 3 and > 1000 nM for human D 1 , D 4 and D 5 receptors. Shows selectivity for presynaptic dopamine autoreceptors at low doses and blocks postsynaptic D 2 /D 3 receptors at higher doses. Preferentially interacts with limbic D 2 -like receptors in vivo . Atypical antipsychotic/antischizophrenic agent with limited extrapyrimidal side effects and a profile distinct from that of haloperidol and remoxipride. |
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Perrault G, Depoortere R, Morel E, Sanger DJ, Scatton B. J Pharmacol Exp Ther. 1997 Jan;280(1):73-82.
Schoemaker H, Claustre Y, Fage D, Rouquier L, Chergui K, Curet O, Oblin A, Gonon F, Carter C, Benavides J, Scatton B. J Pharmacol Exp Ther. 1997 Jan;280(1):83-97.