Amitriptyline hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 2132
• Prices: $59.00
• Sizes: 50 mg
• Function Type: Inhibitor
• Cas Number: 549-18-8
• Chemical Name: 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanaminehydrochloride
• Formula: C20H23N.HCl
• Molecular Weight: 313.86
• Purity: >99 %
• Description: Inhibitor of serotonin and noradrenaline uptake; also activates α 2A -adrenoceptors and antagonizes 5-HT 2 receptors. Displays antinociceptive activity. Tricyclic antidepressant (TCA). Also a TrkA/B agonist. Induces neurite outgrowth in PC12 cells.

Product References

Comparison of the effects of antidepressants and their metabolites on reuptake of - Comparison of the effects of antidepressants and their metabolites on reuptake of

Sanchez C, Hyttel J. Cell Mol Neurobiol. 1999 Aug;19(4):467-89.

Antinociception induced by amitriptyline and imipramine is mediated by - Antinociception induced by amitriptyline and imipramine is mediated by

Ghelardini C, Galeotti N, Bartolini A. Jpn J Pharmacol. 2000 Feb;82(2):130-7.

Antidepressants as analgesics: an overview of central and peripheral mechanisms - Antidepressants as analgesics: an overview of central and peripheral mechanisms

Sawynok J, Esser MJ, Reid AR. J Psychiatry Neurosci. 2001 Jan;26(1):21-9.