Amlexanox

• Supplier: Tocris Bioscience
• Catalog: 4456
• Prices: $89.00, $345.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 68302-57-8
• Chemical Name: 2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylicacid
• Formula: C16H14N2O4
• Molecular Weight: 298.29
• Purity: >99 %
• Description: Selective inhibitor of TANK-binding kinase 1 (TBK1) and IKK ε (IC 50 values are ~1-2 μ M). Displays no effect on IKK α or IKK β at these concentrations. Reversibly lowers weight, increases insulin sensitivity, and reduces inflammation and steatosis in three mouse models of obesity. Exhibits antiallergic activity; inhibits the release of histamine from rat mast cells. Also binds to Hsp90 and inhibits C-terminal chaperone activity in vitro .

Product References

Mechanism of action of an antiallergic agent, amlexanox (AA-673), in inhibiting - Mechanism of action of an antiallergic agent, amlexanox (AA-673), in inhibiting

Makino H, Saijo T, Ashida Y, Kuriki H, Maki Y. Int Arch Allergy Appl Immunol. 1987;82(1):66-71.

Hsp90 is a direct target of the anti-allergic drugs disodium cromoglycate and - Hsp90 is a direct target of the anti-allergic drugs disodium cromoglycate and

Okada M, Itoh H, Hatakeyama T, Tokumitsu H, Kobayashi R. Biochem J. 2003 Sep 1;374(Pt 2):433-41.

An inhibitor of the protein kinases TBK1 and IKK-varepsilon improves - An inhibitor of the protein kinases TBK1 and IKK-varepsilon improves

Reilly SM, Chiang SH, Decker SJ, Chang L, Uhm M, Larsen MJ, Rubin JR, Mowers J, White NM, Hochberg I, Downes M, Yu RT, Liddle C, Evans RM, Oh D, Li P, Olefsky JM, Saltiel AR. Nat Med. 2013 Mar;19(3):313-21.