| Name | AMN 082 dihydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 5659 |
| Prices | $109.00, $459.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Agonist |
| Cas Number | 97075-46-2 |
| Chemical Name | N,N'-Bis(diphenylmethyl)-1,2-ethanediaminedihydrochloride |
| Formula | C28H28N2.2HCl |
| Molecular Weight | 465.45 |
| Purity | >99 % |
| Description | The first selective mGlu 7 agonist. Potently inhibits cAMP accumulation and stimulates GTP γ S binding in recombinant cells and on membranes expressing mGlu 7 (EC 50 = 64 - 290 nM). Selective over other mGluR subtypes and selected ionotropic glutamate receptors up to 10 μ M. Acts via a novel allosteric site and is orally active and brain penetrant. Reduces haloperidol-induced catalepsy in rats. |
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