cAMPS-Rp, triethylammonium salt

Name cAMPS-Rp, triethylammonium salt
Supplier Tocris Bioscience
Catalog 5503
Prices $149.00
Sizes 1 mg
Function Type Antagonist
Cas Number 151837-09-1
Chemical Name (R)-Adenosine,cyclic3',5'-(hydrogenphosphorothioate)triethylammonium
Formula C10H12N5O5PS.C6H15N
Molecular Weight 446.46
Purity >98 %
Description Cell-permeable cAMP analog; acts as a competitive antagonist of cAMP-induced activation of PKA (IC 50 = 11 - 16 μ M) by interacting with cAMP binding sites on the regulatory subunits. Resistant to hydrolysis by phosphodiesterases. Enantiomer cAMPS-Sp, triethylammonium salt (Cat. No. 1333) also available.
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Product References

Competitive cAMP antagonists for cAMP-receptor proteins. - Competitive cAMP antagonists for cAMP-receptor proteins.

Van Haastert PJ, Van Driel R, Jastorff B, Baraniak J, Stec WJ, De Wit RJ. J Biol Chem. 1984 Aug 25;259(16):10020-4.

A mechanistic and kinetic analysis of the interactions of the diastereoisomers of - A mechanistic and kinetic analysis of the interactions of the diastereoisomers of

Rothermel JD, Parker Botelho LH. Biochem J. 1988 May 1;251(3):757-62.

Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I - Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I

Dostmann WR, Taylor SS, Genieser HG, Jastorff B, Doskeland SO, Ogreid D. J Biol Chem. 1990 Jun 25;265(18):10484-91.

Isoproterenol inhibits rod outer segment phagocytosis by both cAMP-dependent and - Isoproterenol inhibits rod outer segment phagocytosis by both cAMP-dependent and

Kuriyama S, Hall MO, Abrams TA, Mittag TW. Invest Ophthalmol Vis Sci. 1995 Mar;36(3):730-6.

PKA and ERK, but not PKC, in the amygdala contribute to pain-related synaptic - PKA and ERK, but not PKC, in the amygdala contribute to pain-related synaptic

Fu Y, Han J, Ishola T, Scerbo M, Adwanikar H, Ramsey C, Neugebauer V. Mol Pain. 2008 Jul 16;4:26.