Amylin (rat)

• Supplier: Tocris Bioscience
• Catalog: 3418
• Prices: $235.00
• Sizes: 500 µg
• Function Type: Agonist
• Cas Number: 124447-81-0
• Formula: C167H272N52O53S2
• Molecular Weight: 3920.43
• Description: Potent endogenous peptide agonist for amylin, calcitonin, CGRP and adrenomedullin receptors (pEC 50 values are 7.06-9.50 at hCT a , 8.11 at rCT a , 7.73-10.1 at hAMY1 a , 9.74 at rAMY1 a , 7.92 at hAMY1 b , 7.78-9.9 at hAMY 2a , 7.94 at hAMY 2b , 8.09-10.8 at hAMY 3a , 9.97 at rAMY and 8.19 at hAMY 3b ) receptors. Suppresses insulin-stimulated glucose uptake. Delays gastric emptying and promotes satiety. Active in vivo .

Product References

Amyloid-beta peptide is toxic to neurons in vivo via indirect mechanisms. - Amyloid-beta peptide is toxic to neurons in vivo via indirect mechanisms.

Walsh DT, Montero RM, Bresciani LG, Jen AY, Leclercq PD, Saunders D, EL-Amir AN, Gbadamoshi L, Gentleman SM, Jen LS. Neurobiol Dis. 2002 Jun;10(1):20-7.

Proteomic identification of proteins oxidized by Abeta(1-42) in synaptosomes: - Proteomic identification of proteins oxidized by Abeta(1-42) in synaptosomes:

Boyd-Kimball D, Castegna A, Sultana R, Poon HF, Petroze R, Lynn BC, Klein JB, Butterfield DA. Brain Res. 2005 May 24;1044(2):206-15. Epub 2005 Apr 15.

Mitochondrial respiratory inhibition and oxidative stress elevate beta-secretase - Mitochondrial respiratory inhibition and oxidative stress elevate beta-secretase

Xiong K, Cai H, Luo XG, Struble RG, Clough RW, Yan XX. Exp Brain Res. 2007 Aug;181(3):435-46. Epub 2007 Apr 12.