Anagrelide hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 3084
• Prices: $149.00, $629.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 58579-51-4
• Chemical Name: 6,7-Dichloro-1,5-dihydroimidazo[2,1-b]quinazolin-2(3H)-onehydrochloride
• Formula: C10H7Cl2N3O.HCl
• Molecular Weight: 292.55
• Purity: >99 %
• Description: Potent type III phosphodiesterase (PDE3) inhibitor (IC 50 = 36 nM). Inhibits platelet aggregation and produces potent thrombocytopenic effects via inhibition of megakaryocyte maturation.

Product References

Anagrelide: a potent and selective inhibitor of platelet cyclic AMP - Anagrelide: a potent and selective inhibitor of platelet cyclic AMP

Gillespie E. Biochem Pharmacol. 1988 Jul 15;37(14):2866-8.

Analysis of the mechanism of anagrelide-induced thrombocytopenia in humans. - Analysis of the mechanism of anagrelide-induced thrombocytopenia in humans.

Mazur EM, Rosmarin AG, Sohl PA, Newton JL, Narendran A. Blood. 1992 Apr 15;79(8):1931-7.

Comparison of the biological activities of anagrelide and its major metabolites - Comparison of the biological activities of anagrelide and its major metabolites

Wang G, Franklin R, Hong Y, Erusalimsky JD. Br J Pharmacol. 2005 Oct;146(3):324-32.