Anandamide (in Tocrisolve™ 100)

• Supplier: Tocris Bioscience
• Catalog: 1339
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 94421-68-8
• Chemical Name: N-(2-Hydroxyethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
• Formula: C22H37NO2
• Molecular Weight: 347.54
• Description: Endogenous cannabinoid and vanilloid receptor agonist, in water-soluble emulsion (for details see Tocrisolve TM 100 , Cat. No. 1684). K i values are 89 and 371 nM for CB 1 and CB 2 receptors respectively; EC 50 values are 18, 31 and 27 nM at GPR55, CB 1 and CB 2 respectively; pK i = 5.68 for rVR1. Also blocks TNF- α -induced NF-kB activation via direct inhibition of IKK. Also available as the pure oil dissolved in ethanol ( Anandamine , Cat. No. 1339). Tocrisolve Control (Cat. No. 1684) also available.

Product References

Pharmacology of cannabinoid receptor ligands. - Pharmacology of cannabinoid receptor ligands.

Pertwee RG. Curr Med Chem. 1999 Aug;6(8):635-64.

Structure-activity relationship for the endogenous cannabinoid, anandamide, and - Structure-activity relationship for the endogenous cannabinoid, anandamide, and

Ross RA, Gibson TM, Brockie HC, Leslie M, Pashmi G, Craib SJ, Di Marzo V, Pertwee RG. Br J Pharmacol. 2001 Feb;132(3):631-40.

Complex regional haemodynamic effects of anandamide in conscious rats. - Complex regional haemodynamic effects of anandamide in conscious rats.

Gardiner SM, March JE, Kemp PA, Bennett T. Br J Pharmacol. 2002 Apr;135(8):1889-96.

Characterization of the anandamide induced depolarization of guinea-pig isolated - Characterization of the anandamide induced depolarization of guinea-pig isolated

Kagaya M, Lamb J, Robbins J, Page CP, Spina D. Br J Pharmacol. 2002 Sep;137(1):39-48.

Anandamide inhibits nuclear factor-kappaB activation through a cannabinoid - Anandamide inhibits nuclear factor-kappaB activation through a cannabinoid

Sancho R, Calzado MA, Di Marzo V, Appendino G, Munoz E. Mol Pharmacol. 2003 Feb;63(2):429-38.

The orphan receptor GPR55 is a novel cannabinoid receptor. - The orphan receptor GPR55 is a novel cannabinoid receptor.

Ryberg E, Larsson N, Sjogren S, Hjorth S, Hermansson NO, Leonova J, Elebring T, Nilsson K, Drmota T, Greasley PJ. Br J Pharmacol. 2007 Dec;152(7):1092-101. Epub 2007 Sep 17.