Anastrozole

Name Anastrozole
Supplier Tocris Bioscience
Catalog 3717
Prices $189.00, $765.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 120511-73-1
Chemical Name α1,α1,α3,α3-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile
Formula C17H19N5
Molecular Weight 293.37
Purity >99 %
Description Potent and highly selective aromatase (CYP19) inhibitor (IC 50 = 15 nM) that has no discernible effect on adrenocorticoid hormone synthesis. Reduces plasma estrogen levels and exhibits antitumor activity in vivo . Orally active.
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Product References

The preclinical pharmacology of "Arimidex" (anastrozole; ZD1033)--a potent, - The preclinical pharmacology of "Arimidex" (anastrozole; ZD1033)--a potent,

Dukes M, Edwards PN, Large M, Smith IK, Boyle T. J Steroid Biochem Mol Biol. 1996 Jul;58(4):439-45.

Anastrozole: a new selective nonsteroidal aromatase inhibitor. - Anastrozole: a new selective nonsteroidal aromatase inhibitor.

Goss PE, Tye LM. Oncology (Williston Park). 1997 Nov;11(11):1697-703; discussion 1707-8.

Anastrozole (Arimidex)--an aromatase inhibitor for the adjuvant setting? - Anastrozole (Arimidex)--an aromatase inhibitor for the adjuvant setting?

Buzdar AU. Br J Cancer. 2001 Nov;85 Suppl 2:6-10.