Anisomycin

• Supplier: Tocris Bioscience
• Catalog: 0867
• Prices: $89.00, $349.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 22862-76-6
• Chemical Name: (2R,3S,4S)-2-[(4-Methoxyphenyl)methyl]-3,4-pyrrolidinediol3-acetate
• Formula: C14H19NO4
• Molecular Weight: 265.31
• Purity: >98 %
• Description: Protein synthesis inhibitor (blocks translation). Potent activator of stress-activated protein kinases (JNK/SAPK) and p38 MAP kinase. Acts as a potent signaling agonist to selectively elicit homologous desensitization of immediate early gene induction (c-fos, fosB, c-jun, junB and junD).

Product References

Anisomycin-activated protein kinases p45 and p55 but not mitogen-activated - Anisomycin-activated protein kinases p45 and p55 but not mitogen-activated

Cano E, Hazzalin CA, Mahadevan LC. Mol Cell Biol. 1994 Nov;14(11):7352-62.

The stress-activated protein kinase subfamily of c-Jun kinases. - The stress-activated protein kinase subfamily of c-Jun kinases.

Kyriakis JM, Banerjee P, Nikolakaki E, Dai T, Rubie EA, Ahmad MF, Avruch J, Woodgett JR. Nature. 1994 May 12;369(6476):156-60.

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating - Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating

Sanchez I, Hughes RT, Mayer BJ, Yee K, Woodgett JR, Avruch J, Kyriakis JM, Zon LI. Nature. 1994 Dec 22-29;372(6508):794-8.

Anisomycin selectively desensitizes signalling components involved in stress - Anisomycin selectively desensitizes signalling components involved in stress

Hazzalin CA, Le Panse R, Cano E, Mahadevan LC. Mol Cell Biol. 1998 Apr;18(4):1844-54.

The protein synthesis inhibitor anisomycin induces macrophage apoptosis in rabbit - The protein synthesis inhibitor anisomycin induces macrophage apoptosis in rabbit

Croons V, Martinet W, Herman AG, Timmermans JP, De Meyer GR. J Pharmacol Exp Ther. 2009 Jun;329(3):856-64.