Anpirtoline hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 1290
• Prices: $165.00, $685.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 99201-87-3
• Chemical Name: 6-Chloro-2-[piperidinyl-4-thio]pyridinehydrochloride
• Formula: C10H13ClN2S.HCl
• Molecular Weight: 265.2
• Purity: >99 %
• Description: Highly potent 5-HT 1B receptor agonist (K i values are 28, 150 and 1490 nM at 5-HT 1B , 5-HT 1A and 5-HT 2 receptors respectively). Decreases central serotonin synthesis and attenuates aggressive behavior in vivo . Also acts as an antagonist at 5-HT 3 receptors (K i = 29.5 nM) and is brain penetrant.

Product References

D-16949 (anpirtoline): a novel serotonergic (5-HT1B) psychotherapeutic agent - D-16949 (anpirtoline): a novel serotonergic (5-HT1B) psychotherapeutic agent

Swedberg MD, Shannon HE, Nickel B, Goldberg SR. J Pharmacol Exp Ther. 1992 Dec;263(3):1015-22.

5-HT3 receptor antagonism by anpirtoline, a mixed 5-HT1 receptor agonist/5-HT3 - 5-HT3 receptor antagonism by anpirtoline, a mixed 5-HT1 receptor agonist/5-HT3

Gothert M, Hamon M, Barann M, Bonisch H, Gozlan H, Laguzzi R, Metzenauer P, Nickel B, Szelenyi I. Br J Pharmacol. 1995 Jan;114(2):269-74.

Aggression escalated by social instigation or by discontinuation of reinforcement - Aggression escalated by social instigation or by discontinuation of reinforcement

de Almeida RM, Miczek KA. Neuropsychopharmacology. 2002 Aug;27(2):171-81.

Effects of anpirtoline on regional serotonin synthesis in the rat brain: an - Effects of anpirtoline on regional serotonin synthesis in the rat brain: an

Watanabe A, Nakai A, Tohyama Y, Nguyen KQ, Diksic M. Nucl Med Biol. 2006 Apr;33(3):325-32. Epub 2006 Mar 9.