Antalarmin hydrochloride

Name Antalarmin hydrochloride
Supplier Tocris Bioscience
Catalog 1954
Prices $199.00, $825.00
Sizes 10 mg, 50 mg
Function Type Antagonist
Cas Number 220953-69-5
Chemical Name N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-aminehydrochloride
Formula C24H34N4.HCl
Molecular Weight 415.01
Purity >99 %
Description Non-peptide corticotropin-releasing hormone receptor 1 (CRF 1 ) antagonist (K i = 1 nM). Suppresses CRF-induced ACTH secretion. Blocks CRF- and novelty-induced anxiety-like behavior in animal models of anxiety.
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Product References

In vivo and in vitro characterization of antalarmin, a nonpeptide - In vivo and in vitro characterization of antalarmin, a nonpeptide

Webster EL, Lewis DB, Torpy DJ, Zachman EK, Rice KC, Chrousos GP. Endocrinology. 1996 Dec;137(12):5747-50.

Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior - Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior

Zorrilla EP, Valdez GR, Nozulak J, Koob GF, Markou A. Brain Res. 2002 Oct 18;952(2):188-99.