AP 18

Name AP 18
Supplier Tocris Bioscience
Catalog 2071
Prices $129.00, $509.00
Sizes 10 mg, 50 mg
Function Type Blocker
Cas Number 55224-94-7
Chemical Name 4-(4-Chlorophenyl)-3-methyl-3-buten-2-oneoxime
Formula C11H12ClNO
Molecular Weight 209.67
Purity >98 %
Description Reversible TRPA1 channel blocker (IC 50 values are 3.1 and 4.5 μ M at human and mouse TRPA1 respectively). Blocks cinnameldehyde-induced but not capsaicin-induced nociception and reverses mechanical hyperalgesia in vivo . Also blocks TRPA1 pore dilation (IC 50 = 10.3 μ M for the inhibition of Yo-Pro uptake).
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Product References

A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological - A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological

Petrus M, Peier AM, Bandell M, Hwang SW, Huynh T, Olney N, Jegla T, Patapoutian A. Mol Pain. 2007 Dec 17;3:40.

Pore dilation occurs in TRPA1 but not in TRPM8 channels. - Pore dilation occurs in TRPA1 but not in TRPM8 channels.

Chen J, Kim D, Bianchi BR, Cavanaugh EJ, Faltynek CR, Kym PR, Reilly RM. Mol Pain. 2009 Jan 21;5:3.

Nitrooleic acid, an endogenous product of nitrative stress, activates nociceptive - Nitrooleic acid, an endogenous product of nitrative stress, activates nociceptive

Taylor-Clark TE, Ghatta S, Bettner W, Undem BJ. Mol Pharmacol. 2009 Apr;75(4):820-9.