AP 811

Name	AP 811
Supplier	Tocris Bioscience
Catalog	4274
Prices	$235.00
Sizes	1 mg
Function Type	Antagonist
Cas Number	124833-45-0
Formula	C46H66N12O8
Molecular Weight	915.1
Description	High affinity, selective ANP clearance receptor (NPR3) antagonist (K i = 0.45 nM). Exhibits >20,000-fold selectivity for NPR3 over NPR1. Inhibits ANP-stimulated Na + /K + pump activity in rabbit ventricular cardiomyocytes in vitro . Also blocks proliferation of rodent neonatal cardiomyocytes seen at low ANP concentrations in vitro .
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Product References

The discovery of non-basic atrial natriuretic peptide clearance receptor - The discovery of non-basic atrial natriuretic peptide clearance receptor

Veale CA, Alford VC, Aharony D, Banville DL, Bialecki RA, Brown FJ, Damewood JR Jr, Dantzman CL, Edwards PD, Jacobs RT, Mauger RC, Murphy MM, Palmer W, Pine KK, Rumsey WL, Garcia-Davenport LE, Shaw A, Steelman GB, Surian JM, Vacek EP. Bioorg Med Chem Lett. 2000 Sep 4;10(17):1949-52.

Natriuretic peptides stimulate the cardiac sodium pump via NPR-C-coupled NOS - Natriuretic peptides stimulate the cardiac sodium pump via NPR-C-coupled NOS

William M, Hamilton EJ, Garcia A, Bundgaard H, Chia KK, Figtree GA, Rasmussen HH. Am J Physiol Cell Physiol. 2008 Apr;294(4):C1067-73. doi:

Differential activation of natriuretic peptide receptors modulates cardiomyocyte - Differential activation of natriuretic peptide receptors modulates cardiomyocyte

Becker JR, Chatterjee S, Robinson TY, Bennett JS, Panakova D, Galindo CL, Zhong L, Shin JT, Coy SM, Kelly AE, Roden DM, Lim CC, MacRae CA. Development. 2014 Jan;141(2):335-45.