L-AP4

• Supplier: Tocris Bioscience
• Catalog: 0101
• Prices: $89.00, $185.00, $755.00
• Sizes: 1 mg, 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 23052-81-5
• Chemical Name: L-(+)-2-Amino-4-phosphonobutyricacid
• Formula: C4H10NO5P
• Molecular Weight: 183.1
• Purity: >99 %
• Description: Selective group III metabotropic glutamate receptor agonist. Synaptic depressant. Agonist at the quisqualate-sensitized AP6 site in hippocampus. Also available as part of the Group III mGlu Receptor Tocriset™ and Mixed mGlu Receptor Tocriset™ . DL Mixture (Cat. No. 0101) and D-isomer (Cat. No. 0102) also available.

Product References

The effects of a series of omega-phosphonic alpha-carboxylic amino acids on - The effects of a series of omega-phosphonic alpha-carboxylic amino acids on

Evans RH, Francis AA, Jones AW, Smith DA, Watkins JC. Br J Pharmacol. 1982 Jan;75(1):65-75.

Molecular diversity of glutamate receptors and implications for brain function. - Molecular diversity of glutamate receptors and implications for brain function.

Nakanishi S. Science. 1992 Oct 23;258(5082):597-603.

Antagonism of the synaptic depressant actions of L-AP4 in the lateral perforant - Antagonism of the synaptic depressant actions of L-AP4 in the lateral perforant

Bushell TJ, Jane DE, Tse HW, Watkins JC, Davies CH, Garthwaite J, Collingridge GL. Neuropharmacology. 1995 Feb;34(2):239-41.

The agonist selectivity of a class III metabotropic glutamate receptor, human - The agonist selectivity of a class III metabotropic glutamate receptor, human

Tones MA, Bendali N, Flor PJ, Knopfel T, Kuhn R. Neuroreport. 1995 Dec 29;7(1):117-20.