2-APB

• Supplier: Tocris Bioscience
• Catalog: 1652
• Prices: $75.00, $249.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 524-95-8
• Chemical Name: 2-Aminoethoxydiphenylborane
• Formula: C14H16BNO
• Molecular Weight: 225.1
• Purity: >98 %
• Description: A functional and membrane permeable D-myo-inositol 1,4,5-trisphosphate (IP 3 ) receptor antagonist (IC 50 = 42 μ M). Stimulates store-operated calcium (SOC) release at low concentrations (< 10 μ M) and inhibits it at higher concentrations (up to 50 μ M). Increases STIM-Orai channel conductance and limits ion selectivity. Modulator of TRP channels; blocks TRPC1, TRPC3, TRPC5, TRPC6, TRPV6, TRPM3, TRPM7, TRPM8 and TRPP2 and at higher concentrations stimulates TRPV1, TRPV2 and TRPV3. Also blocks specific gap channel subtypes.

Product References

2APB, 2-aminoethoxydiphenyl borate, a membrane-penetrable modulator of - 2APB, 2-aminoethoxydiphenyl borate, a membrane-penetrable modulator of

Maruyama T, Kanaji T, Nakade S, Kanno T, Mikoshiba K. J Biochem. 1997 Sep;122(3):498-505.

Block of TRPC5 channels by 2-aminoethoxydiphenyl borate: a differential, - Block of TRPC5 channels by 2-aminoethoxydiphenyl borate: a differential,

Xu SZ, Zeng F, Boulay G, Grimm C, Harteneck C, Beech DJ. Br J Pharmacol. 2005 Jun;145(4):405-14.

Block of specific gap junction channel subtypes by 2-aminoethoxydiphenyl borate - Block of specific gap junction channel subtypes by 2-aminoethoxydiphenyl borate

Bai D, del Corsso C, Srinivas M, Spray DC. J Pharmacol Exp Ther. 2006 Dec;319(3):1452-8. Epub 2006 Sep 19.

Inhibition of the transient receptor potential cation channel TRPM2 by - Inhibition of the transient receptor potential cation channel TRPM2 by

Togashi K, Inada H, Tominaga M. Br J Pharmacol. 2008 Mar;153(6):1324-30.

STIM and Orai: the long-awaited constituents of store-operated calcium entry. - STIM and Orai: the long-awaited constituents of store-operated calcium entry.

Varnai P, Hunyady L, Balla T. Trends Pharmacol Sci. 2009 Mar;30(3):118-28.