Name | APC 366 |
---|---|
Supplier | Tocris Bioscience |
Catalog | 1224 |
Prices | $225.00 |
Sizes | 5 mg |
Function Type | Inhibitor |
Cas Number | 158921-85-8 |
Chemical Name | N-(1-Hydroxy-2-naphthoyl)-L-arginyl-L-prolinamide |
Formula | C22H28N6O4 |
Molecular Weight | 440.5 |
Description | Selective inhibitor of mast cell tryptase (K i = 7.1 μ M) that inhibits tryptase-induced histamine release from human tonsil and lung cells. Reduces airway inflammation and blocks postchallenge airway hyperresponsiveness in vivo . |
Supplier Page | Shop |
Barrios VE, Middleton SC, Kashem MA, Havill AM, Toombs CF, Wright CD. Life Sci. 1998;63(26):2295-303.
He S, Gaca MD, Walls AF. J Pharmacol Exp Ther. 1998 Jul;286(1):289-97.
He S, Aslam A, Gaca MD, He Y, Buckley MG, Hollenberg MD, Walls AF. J Pharmacol Exp Ther. 2004 Apr;309(1):119-26. Epub 2004 Jan 13.