(2 R ,4 R )-APDC

• Supplier: Tocris Bioscience
• Catalog: 3704
• Prices: $239.00, $985.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 169209-63-6
• Chemical Name: (2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylate
• Formula: C6H10N2O4
• Molecular Weight: 174.16
• Purity: >98 %
• Description: A highly selective and relatively potent group II metabotropic glutamate receptor agonist. EC 50 values are 0.4, 0.4, > 100, > 100, > 300 and > 300 μ M for human mGlu 2 , mGlu 3 , mGlu 1 , mGlu 5 , mGlu 4 and mGlu 7 receptors respectively. Centrally active following systemic administration in vivo . Also available as part of the Group II mGlu Receptor Tocriset™ .

Product References

Selective inhibition of forskolin-stimulated cyclic AMP formation in rat - Selective inhibition of forskolin-stimulated cyclic AMP formation in rat

Schoepp DD, Johnson BG, Salhoff CR, Valli MJ, Desai MA, Burnett JP, Mayne NG, Monn JA. Neuropharmacology. 1995 Aug;34(8):843-50.

Synthesis of the four isomers of 4-aminopyrrolidine-2,4-dicarboxylate: - Synthesis of the four isomers of 4-aminopyrrolidine-2,4-dicarboxylate:

Monn JA, Valli MJ, Johnson BG, Salhoff CR, Wright RA, Howe T, Bond A, Lodge D, Spangle LA, Paschal JW, Campbell JB, Griffey K, Tizzano JP, Schoepp DD. J Med Chem. 1996 Jul 19;39(15):2990-3000.

Pharmacological agents acting at subtypes of metabotropic glutamate receptors. - Pharmacological agents acting at subtypes of metabotropic glutamate receptors.

Schoepp DD, Jane DE, Monn JA. Neuropharmacology. 1999 Oct;38(10):1431-76.