Apelin-36 (rat, mouse)

• Supplier: Tocris Bioscience
• Catalog: 2426
• Prices: $419.00
• Sizes: 1 mg
• Function Type: Agonist
• Cas Number: 230299-95-3
• Formula: C185H304N68O43S
• Molecular Weight: 4200.93
• Description: Endogenous APJ receptor agonist that is secreted by adipocytes. Binds with high affinity to APJ receptors (IC 50 = 5.4 nM) and potently inhibits cAMP production in vitro (EC 50 = 0.52 nM). Involved in regulation of cardiovascular function, fluid homeostasis and feeding. Blocks entry of some HIV-1 and HIV-2 strains into NP-2/CD4 cells expressing APJ.

Product References

Apelin peptides block the entry of human immunodeficiency virus (HIV). - Apelin peptides block the entry of human immunodeficiency virus (HIV).

Zou MX, Liu HY, Haraguchi Y, Soda Y, Tatemoto K, Hoshino H. FEBS Lett. 2000 May 4;473(1):15-8.

Molecular properties of apelin: tissue distribution and receptor binding. - Molecular properties of apelin: tissue distribution and receptor binding.

Kawamata Y, Habata Y, Fukusumi S, Hosoya M, Fujii R, Hinuma S, Nishizawa N, Kitada C, Onda H, Nishimura O, Fujino M. Biochim Biophys Acta. 2001 Apr 23;1538(2-3):162-71.